 If you liked Natsume Yuujinchou |  ...then you might like Tegamibachi |
The protagonist is a boy with strange powers, (while Natsume has the power to see Youkai, Lag has the power to show the "heart" of people contained in letters) and has a funny friend that follows him, protecting him anywhere he goes to help someone. Its mostly about bonds and true friendship, where every episode is centered about different characters and their touching stories. There is also a very important character from the past of the protagonist that appears a lot in flashbacks (Reiko/Gauche).